Welcome to HEDD, an integrated human enhancer disease database  


Enhancers are specialized genomic cis-regulatory elements that play a central role in regulating a wide range of important biological functions and processes, whose impairment could result in disease. HEDD, as a central repository of human enhancers and their disease association, can facilitate genomic research of enhancers and their roles in the human diseases. In the current release, HEDD provides the following:
  • 2,793,316 enhancers
  • Comprehensive genomic information on every enhancer, including:
    • Conservation score
    • Regulatory target genes
    • Active cell/tissue types
    • Co-regulatory enhancers
    • Local gene regulatory network
    • Functionally significant genetic variants
    • Overlapping genomic elements (DHS, TFBS, histone marks, and repeats)
  • Enhancer-disease association scores
  • Web-based analytical tools for enhancer visualization and scoring

If you use HEDD in your work, please cite our publication: Wang Z, Zhang Q, Zhang W, Lin JR, Cai Y, Mitra J, Zhang ZD. HEDD: Human Enhancer Disease Database (2018). Nucleic Acids Res, 46, D113-D120.


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[4] Aziz Khan, Xuegong Zhang. dbSUPER: a database of super-enhancers in mouse and human genome. Nucleic Acids Research, 2016, Vol. 44, Database issue.

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